> ## Content Index
> Fetch the complete content index at: https://www.fdaweb.com/llms.txt
> Use this file to discover other available public pages before exploring further.

# CDER Requiring Packaging Changes to Eye Drops
- URL: https://www.fdaweb.com/cder-requiring-packaging-changes-to-eye-drops/
- Published: 2016-03-15T12:00:00.000Z
- Updated: 2026-09-15T02:44:07.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5135080

> CDER [says](http://www.fda.gov/Drugs/DrugSafety/ucm490693.htm?ref=fdaweb.com) it will require packaging design changes for eye drop bottles that have loose plastic safety seals or tamper-evident rings below the bottle cap because they may fall onto the eye when used. It strongly recommends that the bottle/cap design include a positive-retention mechanism similar to those on disposable plastic beverage bottles to prevent the tamper-evident rings from coming off while using the product. The agency has received six adverse events reports associated with loose safety seals on eye drop bottles.