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# Clinical Hold Placed on Ziopharm Leukemia Trial
- URL: https://www.fdaweb.com/clinical-hold-placed-on-ziopharm-leukemia-trial/
- Published: 2018-06-18T12:00:00.000Z
- Updated: 2026-09-15T00:13:57.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5141712

FDA has issued a clinical hold on a Ziopharm Oncology Phase 1 trial to evaluate CD19-specific CAR-T therapies manufactured under point-of-care, and requested additional information to support the IND. The clinical trial is intended to evaluate CAR T cells manufactured with “*Sleeping Beauty”* technology as an investigational treatment for patients with relapsed or refractory, CD19 leukemias and lymphomas. The agency requested additional information related to chemistry, manufacturing and controls, according to the company.