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# Comments Sought on pH-dependent Drug-Drug Interactions
- URL: https://www.fdaweb.com/comments-sought-on-ph-dependent-drug-drug-interactions/
- Published: 2018-05-22T12:00:00.000Z
- Updated: 2026-09-15T00:06:56.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5141500

*Federal Register* notice: FDA has established a public docket to assist with developing a policy or guidance document on assessing pH-dependent drug-drug interactions (DDIs). The agency notes that recent draft guidance documents only focus on enzyme- and transporter-based DDIs and do not include a framework for assessing DDIs caused by drug-induced changes in gastric pH. The agency is seeking comments until 7/23 on best practices in planning and evaluating such drug-drug interactions. To view the notice, click [here](https://www.gpo.gov/fdsys/pkg/FR-2018-05-22/pdf/2018-10927.pdf?ref=fdaweb.com).