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# Complex Innovative Trial Case Studies
- URL: https://www.fdaweb.com/complex-innovative-trial-case-studies/
- Published: 2022-01-18T12:00:00.000Z
- Updated: 2026-09-14T17:28:57.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5150945

FDA has published case study examples to educate stakeholders and provide innovation in the area of complex innovative trial designs (CID). An agency [notice](https://content.govdelivery.com/accounts/USFDA/bulletins/3065d49?ref=fdaweb.com) says the CID pilot meeting program, launched in 2018, is intended to advance the use of complex adaptive, Bayesian, and other novel clinical trial designs. “The program offers sponsors an opportunity for increased interaction with FDA to discuss specific considerations for a proposed CID,” the notice says.

The description of each CID Pilot Meeting Program case study focuses on the single clinical design that was the focus of the pilot program submission. The three studies are [Master Protocol Case Study](http://www.fda.gov/media/155403/download?ref=fdaweb.com), [Lupus Case Study](http://www.fda.gov/media/155404/download?ref=fdaweb.com), and [DLBCL Case Study](http://www.fda.gov/media/155405/download?ref=fdaweb.com).