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# Draft Guide on Major Depressive Disorder Drugs
- URL: https://www.fdaweb.com/draft-guide-on-major-depressive-disorder-drugs/
- Published: 2018-06-22T12:00:00.000Z
- Updated: 2026-09-15T00:15:32.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5141751

*Federal Register* notice: FDA has made available a draft guidance for industry entitled “Major Depressive Disorder: Developing Drugs for Treatment.” The document is intended to assist sponsors in the clinical development of drugs for the monotherapeutic, combination, and adjunctive treatment of major depressive disorder. It addresses FDA’s current thinking on the overall development program and clinical trial designs for antidepressant drug products. To view the notice, click [here](https://www.gpo.gov/fdsys/pkg/FR-2018-06-21/pdf/2018-13297.pdf?ref=fdaweb.com).