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# FDA Confirms Effective Date on Ozone-depleting Substances
- URL: https://www.fdaweb.com/fda-confirms-effective-date-on-ozone-depleting-substances/
- Published: 2017-02-28T12:00:00.000Z
- Updated: 2026-09-14T22:08:58.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5138085

*Federal Register* notice: FDA has confirmed the effective date of 2/23 for a direct final rule that removes an “essential use” designation for certain ozone-depleting substances (ODSs) under the Clean Air Act. The action removes the essential-use exemption for sterile aerosol talc administered intrapleurally by thoracoscopy for human use and for metered-dose atropine sulfate aerosol human drugs administered by oral inhalation. FDA is taking this action because alternative products that do not use ODSs are now available and because these products are no longer being marketed in versions that contain ODSs. To view the 10/26/2017 direct final rule, click [here](https://www.gpo.gov/fdsys/pkg/FR-2016-10-26/pdf/2016-25851.pdf?ref=fdaweb.com). To view the current notice, click [here](https://www.gpo.gov/fdsys/pkg/FR-2017-02-28/pdf/2017-03866.pdf?ref=fdaweb.com).