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# FDA Tells 21 Web Sites to Stop Selling Opioids
- URL: https://www.fdaweb.com/fda-tells-21-web-sites-to-stop-selling-opioids/
- Published: 2018-08-28T12:00:00.000Z
- Updated: 2026-09-15T00:28:37.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5142211

FDA says it has warned four more online networks with a total of 21 Web sites to stop marketing potentially dangerous, unapproved, and misbranded versions of opioids, including tramadol (Ultram). Commissioner **Scott Gottlieb** says in a [statement](https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm618658.htm?ref=fdaweb.com) that the Warning Letters sent by FDA this summer now total 13, covering more than 70 Web sites. “FDA remains resolute in our promise to continue cracking down on these networks to protect the public health,” he says. “We have more operations underway and additional actions planned.”

The statement says the illegal sale of the products is particularly concerning considering that the approved version of tramadol contains a Boxed Warning for a significant risk of serious or even life-threatening adverse effects including addiction, abuse, misuse, life-threatening respiratory depression, and neonatal opioid withdrawal syndrome.

The companies were told to respond with specific actions they are taking to address the agency’s concerns. The notice says that companies that fail to correct the violations may be subject to legal enforcement action.