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# Glycol Testing Guidance
- URL: https://www.fdaweb.com/glycol-testing-guidance/
- Published: 2023-05-09T12:00:00.000Z
- Updated: 2026-09-14T18:30:42.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5154398

FDA has published an immediately effective guidance, *Testing of Glycerin, Propylene Glycol, Maltitol Solution, Hydrogenated Starch Hydrolysate, Sorbitol Solution, and Other High-Risk Drug Components for Diethylene Glycol and Ethylene Glycol*, to alert drug manufacturers, compounders, repackers, and suppliers to the potential health hazard of glycerin and other high-risk drug components contaminated with diethylene glycol (DEG) or ethylene glycol (EG). The [document](https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/premier-nutra-pharma-inc-640210-12092022?ref=fdaweb.com) says “FDA has received and continues to receive (most recently in early 2023) reports about fatal poisonings of consumers who ingested drug products in a liquid dosage form (such as cough, allergy, analgesic, and antiemetic drug products) that were manufactured with DEG- or EG-contaminated components.”

The guidance has information on complying with applicable regulatory requirements and recommendations to help pharmaceutical manufacturers, repackers, other suppliers of high-risk drug components, and compounders prevent the use of glycerin and other high-risk drug components that are contaminated with DEG or EG. “These requirements and recommendations, along with other appropriate measures under current good manufacturing practice, are vital to prevent further consumer poisonings,” it says.