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# Guidance on Compounding Amoxicillin Due to Shortages
- URL: https://www.fdaweb.com/guidance-on-compounding-amoxicillin-due-to-shortages/
- Published: 2022-11-18T12:00:00.000Z
- Updated: 2026-09-14T18:06:58.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5153238

Due to increased demand for amoxicillin oral powder and subsequent shortages, FDA 11/18 issued an [immediately in effect guidance](https://lnks.gd/l/eyJhbGciOiJIUzI1NiJ9.eyJidWxsZXRpbl9saW5rX2lkIjoxMDEsInVyaSI6ImJwMjpjbGljayIsImJ1bGxldGluX2lkIjoiMjAyMjExMTguNjY5MjgyMTEiLCJ1cmwiOiJodHRwczovL3d3dy5mZGEuZ292L3JlZ3VsYXRvcnktaW5mb3JtYXRpb24vc2VhcmNoLWZkYS1ndWlkYW5jZS1kb2N1bWVudHMvY29tcG91bmRpbmctY2VydGFpbi1iZXRhLWxhY3RhbS1wcm9kdWN0cy1zaG9ydGFnZS11bmRlci1zZWN0aW9uLTUwM2EtZmVkZXJhbC1mb29kLWRydWctYW5kLWNvc21ldGljP3V0bV9tZWRpdW09ZW1haWwmdXRtX3NvdXJjZT1nb3ZkZWxpdmVyeSJ9.jSS8hWy%5Fb56p-HcT%5FGppfbtCEJpU7xgwDVUFjgScSOc/s/1255931999/br/148545224502-l?ref=fdaweb.com) on the preparation of beta-lactam oral antibiotic suspension products compounded by pharmacists. The agency says it has received requests for clarification about preparation of compounded versions of the products from FDA-approved tablets and capsules.

“The guidance describes steps to reduce the risk of cross-contamination between these and other products,” the agency says. “Amoxicillin is a beta-lactam drug, and compounding this drug in an environment without appropriate safety measures could lead to cross-contamination of other drug products. Beta-lactam drugs can cause life-threatening allergic reactions in some patients.”

Amoxicillin is commonly used for treating bacterial infections in children, among other uses.