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# Guidance on Evaluating Generic Opioid Abuse Deterrence
- URL: https://www.fdaweb.com/guidance-on-evaluating-generic-opioid-abuse-deterrence/
- Published: 2016-03-25T12:00:00.000Z
- Updated: 2026-09-14T20:51:08.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5135190

*Federal Register* Notice: FDA is making available a draft guidance: *General Principles for Evaluating the Abuse Deterrence of Generic Solid Oral Opioid Drug Products*. It recommends studies, including comparative in vitro studies, that should be conducted to demonstrate that a proposed generic solid oral opioid drug product is no less abuse-deterrent than its reference listed drug. To download this guidance, click [here.](http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM492172.pdf?ref=fdaweb.com) To view this notice, click [here](https://www.gpo.gov/fdsys/pkg/FR-2016-03-25/pdf/2016-06766.pdf?ref=fdaweb.com).