> ## Content Index
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# Guide on Circulating Tumor DNA Biomarker Trials
- URL: https://www.fdaweb.com/guide-on-circulating-tumor-dna-biomarker-trials/
- Published: 2024-12-02T12:00:00.000Z
- Updated: 2026-09-14T14:48:20.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5158279

*Federal Register* notice: FDA is making available a final guidance entitled “Use of Circulating Tumor DNA for Curative-Intent Solid Tumor Drug Development.” The document is intended to help sponsors planning to use the biomarker in cancer clinical trials or to support marketing approval of drugs and biological products for treating solid tumor malignancies in the early-stage (curative-intent) setting. To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2024-11-29/pdf/2024-28033.pdf?ref=fdaweb.com).