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# Guide on Covariate Adjustments in Trials
- URL: https://www.fdaweb.com/guide-on-covariate-adjustments-in-trials/
- Published: 2023-05-26T12:00:00.000Z
- Updated: 2026-09-14T18:34:50.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5154550

*Federal Register* notice: FDA is making available a final guidance entitled “Adjusting for Covariates in Randomized Clinical Trials for Drugs and Biological Products.” The document discusses general recommendations for performing covariate adjustment using linear models, and for performing covariate adjusting using nonlinear models. To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2023-05-26/pdf/2023-11263.pdf?ref=fdaweb.com).