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# Guide on Fecal Microbiota Enforcement Policy
- URL: https://www.fdaweb.com/guide-on-fecal-microbiota-enforcement-policy/
- Published: 2022-11-29T12:00:00.000Z
- Updated: 2026-09-14T18:07:52.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5153275

*Federal Register* notice: FDA is making available a final guidance entitled “Enforcement Policy Regarding Investigational New Drug Requirements for Use of Fecal Microbiota for Transplantation to Treat *Clostridioides difficile* Infection Not Responsive to Standard Therapies.” The document describes the agency’s intended enforcement discretion with respect to IND requirements for using fecal microbiota for transplantation to treat *C.diff* infections. To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2022-11-29/pdf/2022-26000.pdf?ref=fdaweb.com).