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# Guide on Trial Master Protocols During Covid-19
- URL: https://www.fdaweb.com/guide-on-trial-master-protocols-during-covid-19/
- Published: 2021-06-24T12:00:00.000Z
- Updated: 2026-09-14T17:04:47.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5149612

*Federal Register* notice: FDA has made available a final guidance entitled *Covid– 19: Master Protocols Evaluating Drugs and Biological Products for Treatment or Prevention*. The document primarily focuses on the trial design and conduct as well as statistical considerations for master protocols intended to generate substantial effectiveness evidence and adequate safety characterizations. of safety for COVID–19\. To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2021-06-24/pdf/2021-13394.pdf?ref=fdaweb.com).