> ## Content Index
> Fetch the complete content index at: https://www.fdaweb.com/llms.txt
> Use this file to discover other available public pages before exploring further.

# ICH Daily Exposure Maintenance Procedures
- URL: https://www.fdaweb.com/ich-daily-exposure-maintenance-procedures/
- Published: 2017-07-25T12:00:00.000Z
- Updated: 2026-09-14T22:36:17.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5139210

The International Council on Harmonization (ICH) has developed maintenance procedures for revising the permitted daily exposure of solvents included in its Q3C guidance. FDA says an ICH Web page makes available to the public all recommendations, decisions, and other information related to the revision of the Q3C tables and lists.

The FDA [notice](https://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm125820.htm?ref=fdaweb.com) includes links to the maintenance procedures, tables and list, and final recommendations for revision to triethylamine and methylisobutylketone, tetrahydrofuran, N-methylpyrrolidone, and cumene.