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# ICH Guides on Drug Interaction Studies
- URL: https://www.fdaweb.com/ich-guides-on-drug-interaction-studies/
- Published: 2024-08-02T12:00:00.000Z
- Updated: 2026-09-14T14:37:18.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5157492

*Federal Register* notice: FDA is making available a final guidance entitled “M12 Drug Interaction Studies” and the supplemental document entitled “M12 Drug Interaction Studies: Questions and Answers.” The International Council for Harmonization-prepared main document provides general recommendations on evaluating the enzyme and transporter- mediated pharmacokinetic drug-drug interaction potential for investigational drugs. The supplemental questions and answers document addresses concepts related to the evaluation of drug interactions covered in the guidance. To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2024-08-02/pdf/2024-17103.pdf?ref=fdaweb.com).