> ## Content Index
> Fetch the complete content index at: https://www.fdaweb.com/llms.txt
> Use this file to discover other available public pages before exploring further.

# Latest Federal Register Notices
- URL: https://www.fdaweb.com/latest-federal-register-notices-182/
- Published: 2018-06-03T12:00:00.000Z
- Updated: 2026-09-15T00:09:57.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5141596

[**Guide on How to Develop REMS Shared System**](https://www.fdaweb.com/guide-on-how-to-develop-rems-shared-system/)  
*Federal Register* notice: FDA makes available a draft guidance entitled “Development of a Shared System REMS.” 06/01/2018

[**ICH Guide on Q12 Post-approval Drug Changes**](https://www.fdaweb.com/ich-guide-on-q12-post-approval-drug-changes/)  
*Federal Register* notice: FDA makes available a guidance entitled “Q12 Technical and Regulatory Considerations for Pharmaceutical Product Lifecycle Management; International Council for Harmonization.” 05/31/2018

[**Guide on Device Bench Test Reports**](https://www.fdaweb.com/guide-on-device-bench-test-reports/)  
*Federal Register* notice: FDA makes available a draft guide entitled “Recommended Content and Format of Complete Test Reports for Non-Clinical Bench Performance Testing in Premarket Submissions.” 05/31/2018

[**Guide on Drug-related Blood Pressure Effects**](https://www.fdaweb.com/guide-on-drug-related-blood-pressure-effects/)  
*Federal Register* notice: FDA makes available a draft guidance entitled “Assessment of Pressor Effects of Drugs.” 05/31/2018

[**Comments Sought on Trial Data Information Collection**](https://www.fdaweb.com/comments-sought-on-trial-data-information-collection/)  
*Federal Register* notice: FDA seeks comments on an information collection extension for its “Guidance for Clinical Trial Sponsors: Establishment and Operation of Clinical Trial Data Monitoring Committees.” 05/30/2018