> ## Content Index
> Fetch the complete content index at: https://www.fdaweb.com/llms.txt
> Use this file to discover other available public pages before exploring further.

# Latest Federal Register Notices
- URL: https://www.fdaweb.com/latest-federal-register-notices-45/
- Published: 2021-07-05T12:00:00.000Z
- Updated: 2026-09-14T17:04:57.000Z
- Author: David McFarland
- Tags: FDA Policy/General, #legacy-id-D5149647

**7/2/2021**

**Topical and Transdermal Adhesion Assessments Guide**

*Federal Register* notice: FDA has made available a draft guidance entitled *Assessment of Adhesion for Topical and Transdermal Systems Submitted in New Drug Applications*. To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2021-07-02/pdf/2021-14202.pdf?ref=fdaweb.com).

**Guide on CNS Cancer Drugs**

*Federal Register* notice: FDA has made available a final guidance entitled *Evaluating Cancer Drugs in Patients with Central Nervous System Metastases*. To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2021-07-02/pdf/2021-14194.pdf?ref=fdaweb.com).

**Guide on Alternate Electronic Submission Formats**

*Federal Register* notice: FDA has made available a final guidance entitled *Providing Regulatory Submissions in Alternate Electronic Format*. To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2021-07-02/pdf/2021-14201.pdf?ref=fdaweb.com).

**Priority Voucher Awarded to Prometic Bio**

*Federal Register* notice: FDA has issued a priority review voucher to Prometic Bioproduction for gaining approval of a rare pediatric disease product application — Ryplazim (plasminogen, human-tvmh), indicated for treating patients with plasminogen deficiency Type 1 (hypoplasminogenemia). To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2021-07-02/pdf/2021-14191.pdf?ref=fdaweb.com).

**Panel Meeting to Review Keystone Heart 510(k)**

*Federal Register* notice: FDA has announced an 8/3 Medical Devices Advisory Committee meeting of its Circulatory System Devices Panel. The meeting will review a Keystone Heart 510(k) for the TriGuard 3 Cerebral Embolic Protection Device. To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2021-07-02/pdf/2021-14212.pdf?ref=fdaweb.com).

**6/30/2021**

**Comments Sought on MedWatch Info Collection**

*Federal Register* notice: FDA is seeking comments on an information collection extension entitled “MedWatch: The FDA Medical Products Reporting Program” (OMB Control Number 0910-0291). To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2021-06-30/pdf/2021-13943.pdf?ref=fdaweb.com).

**Info Collection on Adverse Event Reporting**

*Federal Register* notice: FDA is seeking comments on an information collection extension entitled “Postmarketing Adverse Experience Reporting and Recordkeeping for Drug and Biologics Products” (OMB Control Number 0910-0230). To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2021-06-30/pdf/2021-13968.pdf?ref=fdaweb.com).

**Corrected Notice on Patient Transport Petition**

*Federal Register* notice: FDA is correcting a 6/5 notice announcing receipt of a petition requesting 510(k) exemption for powered patient transports. The document was published with an incorrect docket number, which is now corrected to read: “Docket No. FDA–2021–P–0424.” To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2021-06-30/pdf/2021-13967.pdf?ref=fdaweb.com).

**6/28/2021**

**Guide on Drug Safety Reporting Requirements**

*Federal Register* notice: FDA is making available a draft guidance entitled *Sponsor Responsibilities—Safety Reporting Requirements and Safety Assessment for Investigational New Drug Application and Bioavailability/Bioequivalence Studies.* To view the notice, click [here](https://www.govinfo.gov/content/pkg/FR-2021-06-28/pdf/2021-13684.pdf?ref=fdaweb.com).