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# PolyPid IND for Phase 3 Surgery Infection Trial
- URL: https://www.fdaweb.com/polypid-ind-for-phase-3-surgery-infection-trial/
- Published: 2018-11-13T12:00:00.000Z
- Updated: 2026-09-15T00:44:16.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5142801

FDA has approved a PolyPid Ltd. IND for it to proceed with a Phase 3 clinical trial involving lead candidate D-Plex\[100\] for preventing post-cardiac surgery sternal infections. The novel product is designed to provide local anti-bacterial activity directly at the surgical site to prevent surgical site infections. “Following D-PLEX\[100\] administration into the surgical site, the drug reservoir constantly releases the entrapped broad-spectrum antibiotic in a controlled manner over a predetermined period of four weeks, thus allowing prolonged infection management with increased potential to eradicate antibiotic resistant bacteria,” the company says.