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# Researchers Find Way to Stop Fibrosis Around Implanted Devices
- URL: https://www.fdaweb.com/researchers-find-way-to-stop-fibrosis-around-implanted-devices/
- Published: 2017-03-28T12:00:00.000Z
- Updated: 2026-09-14T22:14:26.000Z
- Author: David McFarland
- Tags: Devices, #legacy-id-D5138311

Researchers at the Massachusetts Institute of Technology and Boston Children’s Hospital say they have identified a signaling molecule that is key to the process of “fibrosis” in which medical devices implanted in a body for drug delivery, sensing, or tissue regeneration become surrounded by a wall of dense scar tissue that eventually leaves them unable to perform their function. The researchers [report](https://scicasts.com/channels/healthcare-technology/2068-medical-devices/12409-new-study-points-way-to-better-implantable-medical-devices/?ref=fdaweb.com) in the 3/20 [Nature Materials](http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat4866.html?ref=fdaweb.com) (subscription or purchase required) that blocking the signaling molecule prevents the scar tissue from forming.

“This gives us a better understanding of the biology behind fibrosis and potentially a way to modulate that response to prevent the formation of scar tissue around implants,” says study senior author **Daniel Anderson**.

While blocking the surface cell receptors for the CSF1 molecule prevents implant-induced fibrosis from occurring, the report says, the interference does not stop macrophages from carrying out other critical functions.