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# Separate Kayexalate from Other Oral Meds: FDA
- URL: https://www.fdaweb.com/separate-kayexalate-from-other-oral-meds-fda/
- Published: 2017-09-06T12:00:00.000Z
- Updated: 2026-09-14T22:46:54.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5139553

FDA is recommending that patients not take the potassium-lowering drug sodium polystyrene sulfate (Concordia’s Kayexalate and generics) at the same time as other medicines taken orally. An agency drug safety [communication](https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm574763.htm?source=govdelivery&utm%5Fmedium=email&utm%5Fsource=govdelivery) says a study found that sodium polystyrene sulfate binds to many commonly prescribed oral medicines, decreasing the absorption and thus the effectiveness of the other medicines.

To reduce the likelihood of that happening, FDA recommends separating the dosing by at least three hours. And it says the dosing separation should be increased to six hours in patients with gastroparesis or other conditions resulting in delayed emptying of food from the stomach into the small intestine.

The communication says the sodium polystyrene sulfate labels are being updated to include information on the dosing separation.