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# Takara Bio Files DMF for Liquid RetroNectin
- URL: https://www.fdaweb.com/takara-bio-files-dmf-for-liquid-retronectin-2/
- Published: 2019-04-11T12:00:00.000Z
- Updated: 2026-09-15T01:19:58.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5143848

Takara Bio has submitted a Drug Master File to FDA for the liquid formulation of RetroNectin GMP grade. The reagent is often used during the manufacturing of CAR T-cell therapies. “In the manufacturing of such therapies, a patient’s T cells — responsible for immune homeostasis — are extracted, modified to recognize and target tumor cells, then infused back into the patient,” the company says. “Before infusion, the gene-transduced cells are expanded in culture. RetroNectin reagent enables the effective viral transduction of gene products into T lymphocytes and the expansion of naïve T-cell populations in culture.”