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# Vivace’s Hippo Pathway Drug VT3989 Gets Fast Track
- URL: https://www.fdaweb.com/vivaces-hippo-pathway-drug-vt3989-gets-fast-track/
- Published: 2025-10-08T12:00:00.000Z
- Updated: 2026-09-14T15:23:41.000Z
- Author: David McFarland
- Tags: Drugs, #legacy-id-D5160007

Vivace Therapeutics has received an FDA fast track designation for its lead cancer drug VT3989, a first-in-class TEAD autopalmitoylation inhibitor being developed for patients with unresectable malignant mesothelioma that has progressed following treatment with an immune checkpoint inhibitor and platinum-based chemotherapy.

Vivace is currently evaluating VT3989 in a Phase 1 open-label trial (NCT04665206) enrolling patients with refractory metastatic solid tumors, including both pleural and non-pleural forms of mesothelioma. The company says more than 200 patients have been treated so far, with data showing early signs of clinical efficacy and a favorable safety profile.

VT3989 is said to work by blocking the palmitoylation of TEAD proteins, a post-translational modification critical to the function of the Hippo pathway — a signaling network implicated in tumor growth and therapy resistance.