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Medical Devices

KCI Gains De Novo Clearance for Prevena

FDA grants de novo marketing clearance to KCI for Prevena Incision Management System, a negative pressure medical device indicated to aid in reducing ...

Medical Devices

Farapulse Ablation System Given Breakthrough Status

FDA grants Farapulse a breakthrough device designation for its Farapulse Pulsed Field Ablation System and its use in treating drug-refractory, recurre...

SCOTUS Decision Could Increase False Claims Cases: Report

Bloomberg Law says the Supreme Court is expected to rule in June on a case that could increase the number of False Claims Act cases that are filed.

PhRMA Wants Combination Product Guidance Clarified

PhRMA lists seven areas for which it seeks further clarification in an FDA draft guidance on combination product premarket pathway principles.

Human Drugs

ICH Guideline for Clinical Study Considerations

The International Council for Harmonization releases for public comments a revised draft guideline entitled General Considerations For Clinical Studie...

Human Drugs

BMS Says Opdivo Phase 3 Trial Misses Endpoint

Bristol-Myers Squibb says its Phase 3 CheckMate-498 trial evaluating Opdivo (nivolumab) versus temozolomide did not meet its primary endpoint of overa...

Human Drugs

Oncology Drug Reproductive Toxicity Testing Guidance

FDA issues a guidance to help oncology drug sponsors evaluate reproductive toxicity effects of their drugs.

Human Drugs

Real-World Evidence Submission Guidance

FDA issues a draft guidance to help sponsors and applicants document submission of INDs, NDAs, and BLAs that contain real-world evidence.

Federal Register

New DTC Study on Accelerated Approval Disclosures

Federal Register notice: FDA submits to OMB a new information collection entitled Experimental Study of an Accelerated Approval Disclosure.

Federal Register

New Info Collection on Compounding Bulk Drug Substance

Federal Register notice: FDA sends to OMB a new information collection entitled Clinical Use of Bulk Drug Substances Nominated for Use in Compounding ...